Intrinsically disordered proteins (IDPs) have no single well-defined tertiary structure under native conditions. IUPred3 is a combined web interface that allows to identify disordered protein regions using IUPred2 and disordered binding regions using ANCHOR2. IUPred3 is also capable of identifying protein regions that do or do not adopt a stable structure depending on the redox state of their environment. IUPred3 supersedes the previous IUPred and ANCHOR servers. For new features included in IUPred3, see the New features section. The IUPred3 web server can be accessed for free.

For a detailed description of how to run IUPred3 using various features and how to interpret the output, see the How to use and Examples sections. For a simple demonstration of how to input data, see the example 1 or example 2.

In order to see an example or our novel Disorder conservation tool click here!

Enter SWISS-PROT/TrEMBL identifier or accession number

or provide your email address and upload a (multi)FASTA file (max 1MB)

or paste the amino acid sequence

or provide a FASTA formatted alignment file for custom disorder conservation analysis

Choose file

Analysis type

IUPred3 long disorder

ANCHOR2

IUPred3 short disorder

Redox state (experimental)

IUPred3 structural domains

IUPred3 disorder conservation (NEW!)

Advanced options

No smoothing

Medium smoothing

Strong smoothing

Submit